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  <ns1:crib124s1i rdf:about="http://metadb.riken.jp/db/SciNetS_rib124i/crib124s1rib124u17894i">
    <ns1:prib124u2i rdf:resource="http://metadb.riken.jp/db/SciNetS_rib124i/crib124u1rib124u4i"/>
    <ns1:prib124u1i xml:lang="en">&lt;p&gt;Autonomous  mobile genetic elements such as transposons or insertion sequences (IS) encode an enzyme, called transposase, required for excising and inserting the mobile element. The IS21 is among the largest of bacterial IS elements and encodes  a  transposase  designated as istA (ORF1) as well as a second protein istB   (ORF2)   and   represents  the  IS21/IS408/IS1162  family  [&lt;cite idref="PUB00007262"/&gt;].  The transposases  of  IS21-like  IS  contain a helix-turn-helix (HTH) motif, represented by this entry, in the N-terminal part that probably binds to DNA. An integrase catalytic domain (see &lt;db_xref db="INTERPRO" dbkey="IPR001584"/&gt;) forms  the  central  part  of  these  IS21/IS408/IS1162  family transposases.&lt;/p&gt;&lt;p&gt;On  the  basis of sequence similarities, two types of HTH-domains can be found in IS21-like transposases.&lt;/p&gt;&lt;p&gt;The  first,  IS21 transposase-type HTH domain, occurs in transposases from the following elements:&lt;ul&gt; &lt;li&gt;IS21 from &lt;taxon tax_id="287"&gt;Pseudomonas aeruginosa&lt;/taxon&gt;        &lt;/li&gt; &lt;li&gt;IS1326 from P. aeruginosa&lt;/li&gt; &lt;li&gt;IS640 from &lt;taxon tax_id="624"&gt;Shigella sonnei&lt;/taxon&gt;        &lt;/li&gt; &lt;li&gt;IS5376 from &lt;taxon tax_id="1422"&gt;Bacillus stearothermophilus&lt;/taxon&gt;        &lt;/li&gt; &lt;li&gt;IS232 from &lt;taxon tax_id="1428"&gt;Bacillus thuringiensis&lt;/taxon&gt;        &lt;/li&gt; &lt;li&gt;IS21-like from &lt;taxon tax_id="817"&gt;Bacteroides fragilis&lt;/taxon&gt;        &lt;/li&gt; &lt;li&gt;A potential insertion element from &lt;taxon tax_id="83263"&gt;Chelatobacter heintzii&lt;/taxon&gt;        &lt;/li&gt;&lt;/ul&gt;&lt;/p&gt;&lt;p&gt;The  second is a IS408/IS1162 transposase-type HTH domain. Some proteins known to contain this domain:&lt;ul&gt; &lt;li&gt;A putative transposase y4uI from &lt;taxon tax_id="394"&gt;Rhizobium sp.&lt;/taxon&gt; (strain NGR234)&lt;/li&gt; &lt;li&gt;A putative transposase y4bL/y4kJ/y4tB, also from strain NGR234&lt;/li&gt; &lt;li&gt;Transposase from IS408 from &lt;taxon tax_id="292"&gt;Burkholderia cepacia&lt;/taxon&gt;        &lt;/li&gt; &lt;li&gt;Transposase from IS1162 from &lt;taxon tax_id="294"&gt;Pseudomonas fluorescens&lt;/taxon&gt;        &lt;/li&gt;&lt;/ul&gt;&lt;/p&gt;&lt;p&gt;This entry represents the IS21 transposase-type HTH domain.&lt;/p&gt;</ns1:prib124u1i>
    <ns1:prib124s4i rdf:resource="http://metadb.riken.jp/db/SciNetS_rib124i/crib124s1rib124u9057i"/>
    <ns4:attributionURL rdf:resource="http://www.ebi.ac.uk/interpro/ISearch?query=IPR017894"/>
    <rdfs:seeAlso rdf:resource="http://database.riken.jp/sw/item/crib124s1rib124u17894i"/>
    <rdfs:label xml:lang="en">Helix-turn-helix, IS21 transposase-type</rdfs:label>
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